The arrivals of head coach Nuno Espirito Santo and sporting director Fabio Paratici are expected to lead to significant changes at the North London outfit.
Spurs have been heavily linked with a number of fresh faces, including playmaker Bryan Gil who is expected to arrive from Sevilla in the coming days.
At least one new defender will also move to Spurs before the start of the new season, activity which will result in players heading in the opposite direction.
According to talkSPORT, the Premier League side are ready to cash in on Dier, Sanchez and Doherty after their inconsistent performances during the most recent campaign.
While the trio will not be short of offers, Spurs may have to reach a compromise with any interested clubs over their respective asking prices.